Human Milk: A Chemical Love: A Handbook of Conceptual and Theoretical Foundations

Authors

Óscar Orlando Rodríguez Wílchez
Universidad Pedagógica y Tecnológica de Colombia
https://orcid.org/0000-0001-7453-381X
Eliana Margarita Rodríguez Castro
Universidad Pedagógica y Tecnológica de Colombia
https://orcid.org/0009-0003-8690-6451
Lina Fernanda Barrera Sánchez
Universidad Pedagógica y Tecnológica de Colombia
https://orcid.org/0000-0002-0211-8155

Keywords:

breastfeeding, nutrition, child health, immune system, biochemistry, health personnel, disease prevention

Synopsis

Breastfeeding, essential for the nutrition of newborns and infants, has changed over time in its perception and practice. Despite its importance for the well-being of infants, mothers and the global economy, the promotion of breastmilk substitutes has led to a decline in its confidence and use. In addition to the misperceptions created by the industry, the data show the need for increased breastfeeding education and promotion. The purpose of this document is to explore the many facets of breastfeeding, its unique and unsurpassed biochemical and cellular composition. It focuses on reviewing current information about these characteristics to provide a support tool for health professionals. The objective is to enhance information, education, and communication in the health sector, thereby promoting breastfeeding within the community and highlighting its significance as the primary means of improving children’s food security. The promotion of breastfeeding is a low-risk and low-cost intervention with proven benefits in preventing chronic non-communicable diseases, such as cancer, diabetes, hypertension, leukemia, and other disorders, including autism and depression. Breastfeeding also optimizes the immune system by transferring stem cells, leukocytes, epithelial cells, microbiome, prebiotics, probiotics, modulators of gene activity, immunoglobulins, active enzymes, trace elements, water, macro and micronutrients. The aim of this study is to provide a conceptual and theoretical foundation for understanding the biochemical and cellular mechanisms that make breast milk a crucial source of food security for infants. This will be achieved through a review of relevant literature based on documentary research.

Chapters

  • Preliminares
  • Capítulo 1. Leche materna, aspectos generales y beneficios
  • Capítulo 2. Composición de la leche humana
  • Glosario

Downloads

Download data is not yet available.

Author Biographies

Óscar Orlando Rodríguez Wílchez, Universidad Pedagógica y Tecnológica de Colombia

Médico. Universidad de Caldas. Magíster en Educación Universidad Andina Simón Bolívar. Docente Escuela de Medicina Universidad Pedagógica y Tecnológica de Colombia UPTC. Grupo de Investigación Enfermería y Atención Primaria en Salud, Tunja, Colombia.

Eliana Margarita Rodríguez Castro, Universidad Pedagógica y Tecnológica de Colombia

Médica. Universidad Pedagógica y Tecnológica de Colombia. Grupo de Investigación Enfermería y Atención Primaria en Salud. Universidad Pedagógica y Tecnológica de Colombia - UPTC, Tunja, Colombia.


Lina Fernanda Barrera Sánchez, Universidad Pedagógica y Tecnológica de Colombia

Enfermera. Universidad Pedagógica y Tecnológica de Colombia. Magíster en Salud Pública de Loma Linda University. Docente Escuela de Enfermería, Grupo de Investigación Enfermería y Atención Primaria en Salud. Universidad Pedagógica y Tecnológica de Colombia UPTC, Tunja, Colombia.


References

Walters DD, Phan LTH, Mathisen R. The cost of not breastfeeding: global results from a new tool. Health Policy Plan. 2019;34(6):407-417. doi:10.1093/heapol/czz050.

Rollins NC, Bhandari N, Hajeebhoy N, et al; Lancet Breastfeeding Series Group. Why invest, and what it will take to improve breastfeeding practices? Lancet. 2016 Jan 30;387(10017):491-504. doi: 10.1016/S0140-6736(15)01044-2. PMID: 26869576.

Pretorius CE, Asare H, Kruger HS, Genuneit J, Siziba LP, Ricci C. Exclusive Breastfeeding, Child Mortality, and Economic Cost in Sub-Saharan Africa. Pediatrics. 2021;147(3):e2020030643. doi:10.1542/peds.2020-030643.

The Lancet. The 2023 Lancet Series on Breastfeeding. Lancet [Internet]. 2023 feb., [citado 2023 mar. 10]; disponible en: http://www.thelancet-press.com/embargo/BreastfeedingSeries.pdf.

Organización Mundial de la Salud. Código Internacional de Comercialización de Sucedáneos de la Leche Materna [Internet]. Ginebra: Organización Mundial de la Salud; 1981. Disponible en: https://www.who.int/es/publications/i/item/9241541601

World Health Organization. Marketing of breast-milk substitutes: national implementation of the international code, status report 2022 [Internet]. Geneva: World Health Organization; 2022. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/354221/9789240048799-eng.pdf?sequence=1&isAllowed=y [revisado 2023 10]. License: CC BY-NC-SA 3.0 IGO.

Dewey KG, Güngör D, Donovan SM, et al. Breastfeeding and risk of overweight in childhood and beyond: a systematic review with emphasis on sibling-pair and intervention studies. Am J Clin Nutr. 2021;114(5):1774-1790. doi:10.1093/ajcn/nqab206.

Rosen-Carole C, Halterman J, Baldwin CD, et al. Prenatal Provider Breastfeeding Toolkit: Results of a Pilot to Increase Women’s Prenatal Breastfeeding Support, Intentions, and Outcomes. Journal of Human Lactation. 2022;38(1):64-74. doi:10.1177/08903344211008797.

Chuisano SA, Anderson OS. Assessing Application-Based Breastfeeding Education for Physicians and Nurses: A Scoping Review. J Hum Lact. 2020;36(4):699–709. doi:10.1177/0890334419848414.

Rameez RM, Sadana D, Kaur S, et al. Association of Maternal Lactation With Diabetes and Hypertension: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Oct 2;2(10):e1913401. doi: 10.1001/jamanetworkopen.2019.13401. PMID: 31617928; PMCID: PMC6806428.

World Alliance for Breastfeeding Action (WABA). Lactancia materna y seguridad alimentaria [Internet]. Penang: World Alliance for Breastfeeding Action; [fecha de publicación no especificada] [citado 2024 feb. 2]. Disponible en: https://www.waba.org.my/resources/otherlanguages/spanish/seguridad.htm

Ministerio de Salud de la Nación de Argentina. Dirección Nacional de Maternidad, Infancia y Adolescencia. Situación de la lactancia materna en Argentina; 2015.

Salutia Foundation. Ten-year plan for breastfeeding and complementary feeding-PDLMAC 2021-2030. Bogotá: Salutia Foundation.

Ministerio de Salud y Protección Social. Encuesta nacional de situación nutricional ENSIN 2015 [Internet], 2015 [citado 2023 mar. 13]. Disponible en: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/GCFI/documento-metodologico-ensin-2015.pdf

Truchet S, Honvo-Houéto E. Physiology of milk secretion. Best Pract Res Clin Endocrinol Metab. 2017;31(4):367-384.

Uvnäs Moberg K, Prime DK, Andersson O, et al. Maternal plasma levels of oxytocin during breastfeeding-A systematic review. PLoS One. 2020;15(8):e0235806. doi: 10.1371/journal.pone.0235806.

Horta BL, Rollins N, Dias MS, Garcez V, Pérez-Escamilla R. Systematic review and meta-analysis of breastfeeding and later overweight or obesity expands on previous study for World Health Organization. Acta Paediatr. 2023;112(1):34-41. doi: 10.1111/apa.16460. Epub 2022 Jul 1. PMID: 35727183.

Owen CG, Whincup PH, Kaye SJ, et al. Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence. Am J Clin Nutr. 2008 Aug;88(2):305-14. doi: 10.1093/ajcn/88.2.305. Erratum in: Am J Clin Nutr. 2008 Dec;88(6):1707. PMID: 18689365.

Güngör D, Nadaud P, LaPergola CC, Dreibelbis C, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM. Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review. Am J Clin Nutr. 2019 Mar 1;109(Suppl_7):817S-837S. doi: 10.1093/ajcn/nqy311. PMID: 30982877; PMCID: PMC6500931.

Lodge CJ, Tan DJ, Lau MX, Dai X, Tham R, Lowe AJ, Bowatte G, Allen KJ, Dharmage SC. Breastfeeding and asthma and allergies: a systematic review and meta-analysis. Acta Paediatr. 2015;104(467):38-53. PMID: 26192405. doi:10.1111/apa.13132.

De Silva D, Halken S, Singh C, et al. Preventing food allergy in infancy and childhood: Systematic review of randomized controlled trials. Pediatr Allergy Immunol. 2020;31(7):813-26. doi: 10.1111/pai.13273.

Henrick BM, Rodriguez L, Lakshmikanth T, et al. Bifidobacteria-mediated immune system imprinting early in life. Cell. 2021;184(15):3884-3898.e11. doi:10.1016/j.cell.2021.05.030.

Altobelli E, Angeletti PM, Verrotti A, Petrocelli R. The Impact of Human Milk on Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(5):1322. doi:10.3390/nu12051322.

Güngör D, Nadaud P, Dreibelbis C, LaPergola CC, Wong YP, Terry N, Abrams SA, Beker L, Jacobovits T, Järvinen KM, Nommsen-Rivers LA, O’Brien KO, Oken E, Pérez-Escamilla R, Ziegler EE, Spahn JM. Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: a systematic review. Am J Clin Nutr. 2019 Mar 1;109(Suppl_7):838S-851S. doi: 10.1093/ajcn/nqy371. Erratum in: Am J Clin Nutr. 2019 Oct 1;110(4):1041. PMID: 30982875; PMCID: PMC6500925.

Cheng J, Eskenazi B, Widjaja F, Cordero JF, Hendren RL. Improving autism perinatal risk factors: A systematic review. Med Hypotheses. 2019 Jun;127:26-33. doi: 10.1016/j.mehy.2019.03.012. Epub 2019 Mar 23. PMID: 31088644.

Esteban-Figuerola P, Canals J, Fernández-Cao JC, Arija Val V. Differences in food consumption and nutritional intake between children with autism spectrum disorders and typically developing children: A meta-analysis. Autism. 2019;23(5):1079-95. doi: 10.1177/1362361318794179.

Su Q, Sun X, Zhu L, Yan Q, Zheng P, Mao Y, Ye D. Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis. BMC Med. 2021;19(1):90. doi: 10.1186/s12916-021-01950.

Eoh KJ, Kim JH, Lee JY, et al. The preventive effect of breastfeeding against ovarian cancer in BRCA1 and BRCA2 mutation carriers: A systematic review and meta-analysis. Gynecol Oncol. 2021 Oct;163(1):142-147. doi: 10.1016/j.ygyno.2021.07.028. Epub 2021 Jul 23. PMID: 34304906.

Qiu R, Zhong Y, Hu M, Wu B. Breastfeeding and Reduced Risk of Breast Cancer: A Systematic Review and Meta-Analysis. Comput Math Methods Med. 2022 Jan 28;2022:8500910. doi: 10.1155/2022/8500910. PMID: 35126640; PMCID: PMC8816576.

Youseflu S, Savabi-Esfahani M, Asghari-Jafarabadi M, Maleki A. The Protective Effect of Breastfeeding and Ingesting Human Breast Milk on Subsequent Risk of Endometriosis in Mother and Child: A Systematic Review and Meta-Analysis. Breastfeed Med. 2022;17(10):805-816. doi:10.1089/bfm.2022.0126.

Kim S, Park M, Ahn S. The Impact of Antepartum Depression and Postpartum Depression on Exclusive Breastfeeding: A Systematic Review and Meta-Analysis. Clin Nurs Res. 2022;31(5):866-880. doi:10.1177/10547738211053507.

Yuen M, Hall OJ, Masters GA, Nephew BC, Carr C, Leung K, Griffen A, McIntyre L, Byatt N, Moore Simas TA. The Effects of Breastfeeding on Maternal Mental Health: A Systematic Review. Journal of Women’s Health. 2022;31(6):787-807. doi:10.1089/jwh.2021.0504.

Aguilar M, Baena L, Sánchez A, Guisado R, Hermoso E, Mur N. Beneficios inmunológicos de la leche humana para la madre y el niño: revisión sistemática. Nutrición Hospitalaria. 2016;33(2):482-493. https://dx.doi.org/10.20960/nh.526.

Magnus MC, Wallace MK, Demirci JR, Catov JM, Schmella MJ, Fraser A. Breastfeeding and Later-Life Cardiometabolic Health in Women With and Without Hypertensive Disorders of Pregnancy. J Am Heart Assoc. 2023;12(5):e026696. doi:10.1161/JAHA.122.026696.

Pham Q, Patel P, Baban B, Yu J, Bhatia J. Factors Affecting the Composition of Expressed Fresh Human Milk. Breastfeed Med. 2020;15(9):551-558. doi:10.1089/bfm.2020.0195.

García-López R. Composición e inmunología de la leche humana. Acta Pediatr Mex. 2014 Jul;32(4):223-30. Available from: https://ojs.actapediatrica.org.mx/index.php/APM/article/view/494.

Tingö L, Ahlberg E, Johansson L, et al. Non-Coding RNAs in Human Breast Milk: A Systematic Review. Front Immunol. 2021;12:725323. Published 2021 Sep 1. doi:10.3389/fimmu.2021.725323.

Melnik BC, Stremmel W, Weiskirchen R, John SM, Schmitz G. Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development. Biomolecules. 2021 Jun 7;11(6):851. doi: 10.3390/biom11060851.

Ahlberg E, Martí M, Govindaraj D, et al. Immune-related microRNAs in breast milk and their relation to regulatory T cells in breastfed children. Pediatr Allergy Immunol. 2023;34(4):e13952. doi:10.1111/pai.13952

Martinez Galan BS et al. Casein and Whey Protein in the Breast Milk Ratio: Could It Promote Protein Metabolism Enhancement in Physically Active Adults? Nutrients. 2021;13(7):2153. Published 2021 Jun 23. doi:10.3390/nu13072153

Donovan SM. Human Milk Proteins: Composition and Physiological Significance. Nestle Nutr Inst Workshop Ser. 2019;90:93-101. doi:10.1159/000490298

Rio-Aige K, Azagra-Boronat I, Castell M, et al. The Breast Milk Immunoglobulinome. Nutrients. 2021;13(6):1810. Published 2021 May 26. doi:10.3390/nu13061810

Monet Álvarez DE, Álvarez Cortés JT, Gross Ochoa VY. Beneficios inmunológicos de la lactancia materna. Rev Cubana Pediatr. 2022; 94(3): e1915. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312022000300004&lng=es. Epub 20-Jul-2022.

Binns C, Lee M, Low WY. The Long-Term Public Health Benefits of Breastfeeding. Asia Pac J Public Health. 2016;28(1):7-14. doi:10.1177/1010539515624964

Brunser O. Advances in the knowledge about human milk proteins. Rev Chil Pediatr. 2018;89(2):261-269. doi: 10.4067/S0370-41062018000200261. Epub 2018 Apr 3.

Sánchez C, Franco L, Regal P, Lamas A, Cepeda A, Fente C. La leche materna: una fuente de compuestos funcionales con potencial aplicación en nutrición y terapia. Nutrients. 2021;13(3):1026. doi: 10.3390/nu13031026.

Rio-Aige K, Fernández-Bargalló A, Vegas-Lozano E, Miñarro-Alonso A, Castell M, Selma-Royo M, Martínez-Costa C, Rodríguez-Lagunas MJ, Collado MC, Pérez-Cano FJ. Breast milk immune composition varies during the transition stage of lactation: characterization of immunotypes in the MAMI cohort. Front Nutr. 2023 Nov 23;10:1252815. doi: 10.3389/fnut.2023.1252815. PMID: 38075221; PMCID: PMC10702228.

Fouda GG, Jaeger FH, Amos JD, et al. Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk. Proc Natl Acad Sci U S A. 2013;110(45):18220-18225. doi:10.1073/pnas.1307336110.

Morniroli D, et al. Las propiedades antivirales de la leche humana: una multitud de herramientas de defensa de la madre naturaleza. Nutrients. 2021;13(2):694. doi:10.3390/nu13020694.

Liu S, Cai X, Wang J, et al. Six Oligosaccharides’ Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum. Nutrients. 2021;13(11):4017. doi:10.3390/nu13114017.

Natividad JM, et al. Human Milk Oligosaccharides and Lactose Affect Differentially Infant Gut Microbiota and Intestinal Barrier In Vitro. Nutrients. 2022;14(12):2546. doi:10.3390/nu14122546.

Martín-Peláez S, Cano-Ibáñez N, Pinto-Gallardo M, Amezcua-Prieto C. The Impact of Probiotics, Prebiotics, and Synbiotics during Pregnancy or Lactation on the Intestinal Microbiota of Children Born by Cesarean Section: A Systematic Review. Nutrients. 2022;14(2):341. doi:10.3390/nu14020341.

Crepinsek MA, Taylor EA, Michener K, Stewart F. Interventions for preventing mastitis after childbirth. Cochrane Database Syst Rev. 2020;(9):CD007239. doi:10.1002/14651858.CD007239.pub4.

Aceti A, et al.; Italian Society of Neonatology. Probiotics Prevent Late-Onset Sepsis in Human Milk-Fed, Very Low Birth Weight Preterm Infants: Systematic Review and Meta-Analysis. Nutrients. 2017;9(8):904. doi:10.3390/nu9080904.

Dos Reis Buzzo Zermiani AP, et al. Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis. Complement Ther Med. 2021;63:102781. doi:10.1016/j.ctim.2021.102781.

Ho NT, et al. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations. Nat Commun. 2018;9(1):4169. doi:10.1038/s41467-018-06473-x.

Zhou Y, et al. Dynamic Changes in Human Milk Oligosaccharides in Chinese Population: A Systematic Review and Meta-Analysis. Nutrients. 2021;13(9):2912. doi:10.3390/nu13092912.

Koletzko B. Lípidos en la leche materna [Internet]. [citado 2023 mayo 24]. Disponible en: http://www.neopuertomontt.com/Index_Archivos/LecheMaternaAnalesNestle2017/Lipidos.pdf.

Stinson LF, George AD. Lípidos de la leche humana y pequeños metabolitos: orígenes maternos y microbianos. Metabolites. 2023;13(3):422. doi:10.3390/metabolo13030422.

Bronsky J, et al. Palm Oil and Beta-palmitate in Infant Formula: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2019;68(5):742-760. doi:10.1097/MPG.0000000000002307.

Hlusko LJ, McNelis MG. Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion. Acta Paediatr. 2022;111(7):1313-1318. doi:10.1111/apa.16358.

Conway MC, McSorley EM, Mulhern MS, Strain JJ, van Wijngaarden E, Yeates AJ. Influence of fatty acid desaturase (FADS) genotype on maternal and child polyunsaturated fatty acids (PUFA) status and child health outcomes: a systematic review. Nutr Rev. 2020;78(8):627-646. doi:10.1093/nutrit/nuz086.

Robinson DT, Palac HL, Baillif V, Van Goethem E, Dubourdeau M, Van Horn L, et al. Long chain fatty acids and related pro-inflammatory, specialized pro-resolving lipid mediators and their intermediates in preterm human milk during the first month of lactation. Prostaglandins Leukot Essent Fatty Acids. 2017;121:1-6. doi:10.1016/j.plefa.2017.05.003.

Gao C, Miller J, Middleton PF, Huang YC, McPhee AJ, Gibson RA. Changes to breast milk fatty acid composition during storage, handling and processing: A systematic review. Prostaglandins Leukot Essent Fatty Acids. 2019;146:1-10. doi:10.1016/j.plefa.2019.04.008.

Neu J. Mother’s Own Milk: How Does It Differ from Donor Milk for the Baby. Breastfeed Med. 2019;14(S1):S3–S4. doi:10.1089/bfm.2019.0036.

Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia: ¿Necesitan las madres lactantes suplementos nutricionales? An Pediatr (Barc). 2016;84(6):347.e1-347.e3477. doi:10.1016/j.anpedi.2015.07.024.

De Souza Mesquita LM, Mennitti LV, de Rosso VV, Pisani LP. The role of vitamin A and its pro-vitamin carotenoids in fetal and neonatal programming: gaps in knowledge and metabolic pathways. Nutr Rev. 2021;79(1):76-87. doi:10.1093/nutrit/nuaa075.

Lockyer F, McCann S, Moore SE. Breast Milk Micronutrients and Infant Neurodevelopmental Outcomes: A Systematic Review. Nutrients. 2021;13(11):3848. doi:10.3390/nu13113848.

Cabezuelo MT, Zaragozá R, Barber T, Viña JR. Role of Vitamin A in Mammary Gland Development and Lactation. Nutrients. 2020;12(1):80. https://doi.org/10.3390/nu12010080.

Araki S, Shirahata A. Vitamin K Deficiency Bleeding in Infancy. Nutrients. 2020;12(3):780. doi:10.3390/nu12030780.

Lucchetta RC, Cavicchioli SA, Gini ALR, et al. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. Sao Paulo Med J. 2021;139(6):545-555. Published 2021 Sep 27. doi:10.1590/1516-3180.2020.0799.R1.0904221.

Da Silva AGCL, De Sousa Rebouças A, Mendonça BMA, Silva DCNE, Dimenstein R, Ribeiro KDDS. Relationship between the dietary intake, serum, and breast milk concentrations of vitamin A and vitamin E in a cohort of women over the course of lactation. Matern Child Nutr. 2019;15(3):e12772. doi:10.1111/mcn.12772.

Zhong X, Xiong Y, Wei D, et al. The influence of maternal vitamin D supplementation on infant vitamin D status: A systematic review and meta-analyses. Complement Ther Med. 2020;52:102491. doi:10.1016/j.ctim.2020.102491.

Wagner CL, Hulsey TC, Ebeling M, et al. Safety Aspects of a Randomized Clinical Trial of Maternal and Infant Vitamin D Supplementation by Feeding Type Through 7 Months Postpartum. Breastfeed Med. 2020;15(12):765-775. doi:10.1089/bfm.2020.0056.

Donohue JA, Solomons NW, Hampel D, Shahab-Ferdows S, Orozco MN, Allen LH. Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial. Am J Clin Nutr. 2020;112(3):669-682. doi:10.1093/ajcn/nqaa147.

Measelle JR, Baldwin DA, Gallant J, et al. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life. Ann N Y Acad Sci. 2021;1498(1):116-132. doi:10.1111/nyas.14610.

Parpia TC, Elwood SE, Scharf RJ, et al. Baseline Characteristics of Study Participants in the Early Life Interventions for Childhood Growth and Development in Tanzania (ELICIT) Trial. Am J Trop Med Hyg. 2020;103(4):1397-1404. doi:10.4269/ajtmh.19-0918.

Von Salmuth V, Brennan E, Kerac M, McGrath M, Frison S, Lelijveld N. Maternal-focused interventions to improve infant growth and nutritional status in low-middle income countries: A systematic review of reviews. PLoS One. 2021;16(8):e0256188. Published 2021 Aug 18. doi:10.1371/journal.pone.0256188.

Wilson RD, O’Connor DL. Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects. Prev Med Rep. 2021;24:101617. Published 2021 Oct 25. doi:10.1016/j.pmedr.2021.101617.

Wahbeh F, Manyama M. The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review. Int J Dev Neurosci. 2021;81(5):386-406. doi:10.1002/jdn.10113.

Dror DK, Allen LH. Vitamin B-12 in Human Milk: A Systematic Review. Adv Nutr. 2018;9(suppl_1):358S-366S. doi:10.1093/advances/nmx019.

Torsvik IK, Ueland PM, Markestad T, Midttun Ø, Bjørke Monsen AL. Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial. BMC Pediatr. 2015;15:218. doi:10.1186/s12887-015-0533-2.

Lucchetta RC, Cavicchioli SDA, Gini ALR, Forgerini M, Varallo FR, Nadai MND, et al. Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis. Sao Paulo Med J. 2021;139:545-555.

Dror DK, Allen LH. Overview of Nutrients in Human Milk. Adv Nutr. 2018;9(suppl_1):278S-294S. doi:10.1093/advances/nmy022

Shertukde SP, Cahoon DS, Prado B, Cara KC, Chung M. Calcium Intake and Metabolism in Infants and Young Children: A Systematic Review of Balance Studies for Supporting the Development of Calcium Requirements. Adv Nutr. 2022;13(5):1529-1553. doi:10.1093/advances/nmac003

Maru M, Birhanu T, Tessema DA. Calcium, magnesium, iron, zinc and copper, compositions of human milk from populations with cereal and ‘enset’ based diets. Ethiop J Health Sci. 2013;23(2):90-97.

Linglart A, Imel EA, Whyte MP, Portale AA, Högler W, Boot AM, Padidela R, Van’t Hoff W, Gottesman GS, Chen A, Skrinar A, Scott Roberts M, Carpenter TO. Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia. J Clin Endocrinol Metab. 2022;107(3):813-24. doi: 10.1210/clinem/dgab729.

Zhang Y, Xun P, Chen C, et al. Magnesium levels in relation to rates of preterm birth: a systematic review and meta-analysis of ecological, observational, and interventional studies. Nutr Rev. 2021;79(2):188-199. doi:10.1093/nutrit/nuaa028

Brion LP, Heyne R, Lair CS. Role of zinc in neonatal growth and brain growth: review and scoping review [published correction appears in Pediatr Res. 2021 Mar 2]. Pediatr Res. 2021;89(7):1627-1640. doi:10.1038/s41390-020-01181-z

Heydarian F, Nakhaei AA, Majd HM, Bakhtiari E. Zinc deficiency and febrile seizures: a systematic review and meta-analysis. Turk J Pediatr. 2020;62(3).

Christian P, Smith ER, Lee SE, Vargas AJ, Bremer AA, Raiten DJ. The need to study human milk as a biological system. Am J Clin Nutr. 2021;113(5):1063-1072. doi:10.1093/ajcn/nqab075

Jin Y, Coad J, Weber JL, Thomson JS, Brough L. Selenium Intake in Iodine-Deficient Pregnant and Breastfeeding Women in New Zealand. Nutrients. 2019;11(1):69. Published 2019 Jan 1. doi:10.3390/nu11010069

Cabezas-Sanchez P, Rainieri S, Conlledo N, et al. Impact of selenium co-administration on methylmercury exposed eleutheroembryos and adult zebrafish (Danio rerio): Changes in bioaccumulation and gene expression. Chemosphere. 2019;236:124295. doi:10.1016/j.chemosphere.2019.07.026

Rodriguez-Diaz E, Pearce EN. Iodine status and supplementation before, during, and after pregnancy. Best Pract Res Clin Endocrinol Metab. 2020;34(4):101430. doi:10.1016/j.beem.2020.101430

Martínez M, Soldevila B, Lucas A, Velasco I, Vila L, Puig-Domingo M. Hypothyroidism during pregnancy and its association to perinatal and obstetric morbidity: a review. Endocrinol Diabetes Nutr (Engl Ed). 2018;65(2):107-113. doi:10.1016/j.endinu.2017.11.009

Liu S, Sharp A, Villanueva E, Ma ZF. Breast Milk Iodine Concentration (BMIC) as a Biomarker of Iodine Status in Lactating Women and Children <2 Years of Age: A Systematic Review. Nutrients. 2022;14(9):1691. Published 2022 Apr 19. doi:10.3390/nu14091691

Machamba AAL, Priore SE, Macedo MS, Franceschini SDCC. Ingestion of supplements and fortified food with iodine on the breast milk iodine concentration in deficiency areas: a systematic review. Afr Health Sci. 2021;21(3):1346-1354. doi:10.4314/ahs.v21i3.46

Mane S, Taneja S, Madala JS, Agarkhedkar S, Khetan M. Study of Stem Cells in Human Milk. Cureus. 2022;14(3):e23701. Published 2022 Mar 31. doi:10.7759/cureus.23701.

Ninkina N, Kukharsky MS, Hewitt MV, et al. Stem cells in human breast milk. Human Cell. 2019;32:223-230. doi: 10.1007/s13577-019-00251-7.

Kersin SG, Özek E. Breast milk stem cells: Are they magic bullets in neonatology? Turk Arch Pediatr. 2021 May 1;56(3):187-191. doi: 10.5152/TurkArchPediatr.2021.21006. PMID: 34104907; PMCID: PMC8152646.

Edwards CA, Van Loo-Bouwman CA, Van Diepen JA, et al. A systematic review of breast milk microbiota composition and the evidence for transfer to and colonisation of the infant gut. Benef Microbes. 2022;13(5):365-381. doi:10.3920/BM2021.0098.

Leo S, Curtis N, Zimmermann P. The neonatal intestinal resistome and factors that influence it-a systematic review. Clin Microbiol Infect. 2022;28(12):1539-1546. doi:10.1016/j.cmi.2022.07.014

Togo A, Dufour JC, Lagier JC, Dubourg G, Raoult D, Million M. Repertoire of human breast and milk microbiota: a systematic review. Future Microbiol. 2019;14:623-641. doi:10.2217/fmb-2018-0317

Smith, J. Investigación documental: métodos y técnicas. 3.a ed. Madrid: Editorial Académica; 2020.

Aslebagh R, Channaveerappa D, Pentecost BT, Arcaro KF, Darie CC. Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery. Adv Exp Med Biol. 2019;1140:451-467. doi: 10.1007/978-3-030-15950-4_26. PMID: 31347064.

García, M. Técnicas de Investigación Documental. Rev Docum Cient. 2019;12(3):45-60.

Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO). Guía de Investigación Documental. París: UNESCO; 2018.

Cohen L, Manion L, Morrison K. Research methods in education. 7th ed. London: Routledge; 2018.

Smith J, Brown A. Research Methods in Psychology. J Psychol Res. 2020;50(3):245-260.

Brown R, Smith J. Seguridad alimentaria y nutrición: conceptos fundamentales. 2.a ed. Barcelona: Ediciones NutriSalud; 2021.

García M, Pérez A. Seguridad Alimentaria en América Latina. Rev Nutr Lat Am. 2019;30(2):120-135.

Organización de las Naciones Unidas para la Alimentación y la Agricultura (FAO). Estado de la seguridad alimentaria y nutrición en el mundo 2022. Roma: FAO; 2022.

Smith, A. Composición nutricional y beneficios de la leche humana. Rev Nutr. 2022;45(2):123-135.

Brown, L. Lactancia materna: fundamentos y prácticas. 2.a ed. Barcelona: Ediciones Maternidad; 2021.

Pérez, M. Beneficios de la lactancia materna: una revisión. Rev Pediatr. 2022;40(1):45-60.

Organización Mundial de la Salud (OMS). Iniciativa hospitales amigos de los niños: diez pasos para una lactancia materna exitosa. Ginebra: OMS; 2019.

López, A. Beneficios de la lactancia materna: una revisión de la literatura. Rev Salud Materno-Infantil. 2022;20(3):245-260.

Organización Mundial de la Salud. Lactancia materna exclusiva [Internet]. Ginebra: Organización Mundial de la Salud; [fecha de acceso 2024 feb. 2]. Disponible en: https://www.who.int

Mamá amamantando al bebé

Downloads

Published

5 July 2024

Details about this monograph

ISBN-13 (15)

978-958-660-860-2